Adjunctive therapy to diet for patients w/ primary (heterozygous familial & non-familial) hypercholesterolaemia in combination w/ statins, who are not appropriately controlled w/ statins alone, or as monotherapy in whom a statin is considered inappropriate or not tolerated. Adjunctive therapy to diet in patients w/ homozygous familial hypercholesterolaemia (HoFH). Adjunctive therapy to diet in patients w/ homozygous familial sitosterolaemia (phytosterolaemia). Reduction of risk of major CV events in patients w/ chronic kidney disease in combination w/ simvastatin. Reduction of risk of CV events (CV death, non-fatal MI, non-fatal stroke, hospitalization for unstable angina or need for revascularization) in patients w/ CHD in combination w/ a statin.
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